We seek to understand how microscopic events produce macroscopic organs and disease. Our model is the kidney, a beautiful, complex, and vital organ. We use human iPS cell-derived organoids, CRISPR gene editing, and high throughput screening to guide development of 21st century therapies.
Current research areas include polycystic kidney disease, cilia, glomerular disease, COVID-19, diabetic kidney disease, nephropathic cystinosis, and kidney regeneration.